Psychopharmacology and Mental Health

Psychopharmacology and Mental Health

In the treatment of psychosis through medication, Seroquel is not the only drug that can be prescribed, and not the only drug with side effects and withdrawal symptoms. Some of the other drugs commonly prescribed to patients suffering from psychosis are Clozapine (Clozaril), Iloperidone (Fanapt), Lurasidone (Latuda), and Rexulti (Brexpoprazole) (Linda, 2017). Clozaril is known as one of the most effective antipsychotics due to its higher affinity for the limbic areas of the brain rather than the striatal areas (Linda, 2017). Other than this key characteristic, it works similarly to Seroquel including its side effects. Fanapt is an antipsychotic that is structurally different from the other atypical antipsychotics (Linda, 2017). This drug works as an antagonist for both D2 and 5-HT2 receptors with a low affinity for histamine and muscarinic receptors (Linda, 2017). The effects of this drug causes minimal weight gain, but it is associated with orthostatic hypotension (alpha blockade) therefore not making it any more effective than existing atypical antipsychotics (Linda, 2017).

Latuda is a strong antagonist of both D2 and 5-HT2 receptors with little interaction with histamine, therefor causing minimal weight gain (Linda, 2017). The sedation, and mood improvement effects of this drug are apparently caused by its antagonistic interactions with 5-HT7 receptors (Linda, 2017). It is suggested that this drug could potentially improve cognitive functioning by promoting nerve growth due to an upregulation of brain-derived neurotropic factors (BDNF) in the PFC (Linda, 2017). Brexpoprazole is a newer antipsychotic that acts on D2 and 5-HT1A receptors as a partial agonist, and 5-HT2A receptors as an antagonist (Linda, 2017). This drug also promotes nerve growth in the PFC like Latuda, and has a risk for weight gain (Linda, 2017).


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Christy and Brigitte LewisChristy Lewis holds a Master’s Degree in Social Work from the University of Texas at Arlington and a Doctorate in Clinical Psychology from The Professional School of Psychology.. She is a Licensed Clinical Social Worker (LCSW) and has counseled for a combined 17 years in several clinical and medical settings and has offered career/life coaching for an additional 10 years. Christy is also Board Certified in Biofeedback and Neurofeedback through BCIA, the Biofeedback Certification International Alliance organization.Brigitte graduated in August 2020 from Baylor University in Waco, Texas with a Bachelor of Science degree in Neuroscience. She is currently working toward her BCN (Board Certification in Neurofeedback) certification. Brigitte currently works at the Biofeedback, Education, & Training Center in Plano, Texas as a Sleep/Health Coach and Clinical Intake Coordinator. Sleep/Health Coaching includes providing new clients with educational information regarding behavioral changes and sleep hygiene to help improve overall perceived sleep quality. In the future, Brigitte plans to attend graduate school to study Clinical Psychology with an emphasis on sleep quality and how it affects overall health.

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